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CD23 interacts with IgE-Fc with the hinge location between Cε3 and Cεfour domains (Fig. 2j), favoring a closed conformation of Cεthree domains34. Comparison on the CD23 and ligelizumab conversation web-sites on IgE implies fairly insignificant overlap among binding web pages of both of these IgE ligands (Fig. 2k). On top of that, the orientation from the ligelizumab VHVL domains on IgE (Fig. 2g) implies which the ligelizumab Fab would challenge faraway from the IgE and would not sterically overlap bound CD23, suggesting that Opposition for IgE surface area subsites plus the stabilization of an open Cεthree conformation could be the primary system of CD23 inhibition.